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Oxyshred Hardcore Review

Posted on January 1, 2020

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EHP Labs are a massive global name in sports and exercise supplementation, offering a range of products that includes protein powders, intra-workouts and thermogenic enhancers.

 

The worldwide popularity of Oxyshred has been no joke, and has found its way into a huge range of retail outlets and online stores. This caffeinated fat-burning powder claims to deliver more energy and motivation for the gym, and to help you get lean or stay lean in the process, amongst many other purported benefits.

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Recently, Oxyshred Hardcore hit the shelves. And it shook the foundations of the earth as people stormed into supplement stores to snatch their tub of the Grape-Bubblegum flavoured powder.

 

Oxyshred Hardcore contains many of the same ingredients as its predecessor, yet with a slightly different spin and more kick to get you moving in the right direction—that is, towards the gym and not away from it.

 

Let’s pull apart this thermogenic and take a look at the main differences between the original and its new hard-core iteration.

 

How Much Caffeine in Oxyshred Hardcore

Each 4.8g serve of Oxyshred Hardcore contains 255mg of caffeine derived from caffeine anhydrous (pure caffeine powder), Guarana Seed Extract and Green Coffee Bean Extract.

 

This 255mg of caffeine contained in each scoop of Oxyshred Hardcore is equivalent to approximately 2 ½ cups of standard strength coffee.

 

The original Oxyshred contains 150mg of caffeine per 5.8g serve. So if you are unsure of your level of caffeine tolerance, it would be best to start with the original formulation—and even then a ¼ to ½ dose to be on the safe side.

 

If you’ve been using the original product for some time and aren’t feeling the effects of the caffeine like you used to, there are only really two choices: take a week or two off to re-sensitize to the effects of this stimulant or increase your dosage.

 

It’s also important to consider your caffeine intake from other sources as well, such as coffee, caffeinated protein powders or soft drinks and energy drinks.

 

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And it’s always worth a mention that it’s important to be cautious when it comes to caffeinated powder and stimulants. The more slight of frame and body-size you are, the more likely you are to take too much.

 

Fat-Burning: How Much Carnitine is Enough?

EHP Labs Oxyshred Hardcore contains a proprietary 1.75 gram blend of Acetyl L-Carnitine Hydrochloride (HCL) and Glycine Propionyl-L-Carnitine HCL in each serve.

 

The original formulation offers a fat-burning matrix of 2.003g grams, the first ingredient of which is Acetyl L-Carnitine. However, this proprietary blend contains 11 ingredients in total.

 

Oxyshred-Hardcore-Grape-Bubblegum.jpgIt would be fair to assume that each serve of either product will contain around 1.5 grams of Acetyl L-Carnitine or less—hopefully not too much less. The original formulation has certainly been toned down in this regard, as a previous formulation declared on the label that it contained 3.5 grams of Acetyl L-Carnitine per serve.

 

So, the question remains … where is the evidence pointing towards in term of dosage? Do we need a high dose like Citrulline Malate (6-8g) to experience the full fat-burning benefit, or do we only need hundreds of milligrams like L-Theanine?

 

For the purposes of weight-loss, a meta-analysis was published in 2016 that reviewed 13 years of published research. This type of article can be great at offering a better understanding of a supplement than any one piece of research alone.

 

The overall conclusion was in the affirmative for Carnitine as a weight loss adjunct, with a suggested daily dosage of 1.8 to 4 grams 1. As this is quite a big dosage range, it would be best to take into consideration your lean body mass.

 

That is, if you are lean or lean-ish and weight 120kg or more, start dosing at the higher end of this range. If you are of average height or less and are slight of frame and build, then start with 1.8 grams daily.

 

Other Benefits of Carnitine

Carnitine is a fascinating dipeptide, made up of the two amino acids Methionine and Lysine. And fat-burning is actually the least of what it can do.

 

Here’s a list of potential benefits associated with Acetyl L-Carnitine, based on clinical trials:

  • Reduced Muscle Soreness and Markers of Muscle Damage after Exercise 2.
  • Improved Blood Flow and Oxygenation of Muscle Mass 2.
  • Increased Muscle Mass in Older Adults 2.
  • Improved Clinical Status in Chronic Fatigue Syndrome 3.
  • Reduced Depressive Symptoms—might work well in combination with Agmatine Sulfate in this regard 4,5.
  • Enhanced Antioxidant Status 4,6.
  • Increased Lifting Volume (demonstrated with Bench Press and Leg Press) 6.
  • Nerve Protectant and Nootropic Effects (may support learning, memory and neuronal energetics) 2,4,7.

 

This is no doubt an incomplete list, as one has only so much time to research—sigh. It is also worth remembering that when it comes to understanding amino acids and natural peptides like Carnitine, scientific research really is still in its infancy.

 

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There is likely more benefit to gain for vegans and vegetarians in supplementing with Carnitine, which is due to the fact that research confirms levels tend to be lower 8. This is likely caused by a reduced dietary methionine and lysine intake.

 

Carnitine is consumed on pescetarian and omnivorous diets, though this does not mean that supplementation will be without benefit. These same principles apply to Creatine as well.   

 

Calorie Content

Like most EHP Labs products, there isn’t too much to worry about when it comes to energy values. Each 4.8 gram serve of Oxyshred Hardcore contains 5 calories, derived from 0.9 grams of carbohydrates and small amount of dietary fibre.

 

This is an identical calorie content to the original product, both of which will certainly keep calorie-counters and keto-enthusiasts happy.

 

Does Oxyshred Hardcore Work?

Yes, it certainly can assist with weight loss. Just the Acetyl L-Carnitine and Caffeine alone have a solid-enough body of scientific evidence to confirm their thermogenic effects.

 

However, it is not recommended that you rely exclusively on a weight loss product as the sole means for weight loss, I.e., without exercise or dietary changes. In case your hopes have just been dashed away, let’s dig a little deeper into this one—after all, it is a weight loss product, right?

 

Even closely adhering to an energy-balanced diet, in which you are consuming as many calories as you are expending (or close to) over a long period of time, fat-burning products may still not get the job done.

 

So why take them?

 

It might help to look at it this way. When most scientific research is undertaken with a weight loss aid, like capsaicin for instance, typically two or more groups are studied. One group will take the capsaicin and the other will use a placebo (inactive pill).

 

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However, both groups are usually put on an exercise program, which may or may not involve the strict adherence to a controlled diet. Then, the researchers assess the difference between the two groups.

 

If the treatment group (capsaicin in this case) loses more weight than the placebo group, than capsaicin is said to enhance fat-loss and to have thermogenic properties. However, rarely is a nutrient, herbs or amino acid studied for weight loss without some sort of exercise or dietary intervention.

 

So it’s very hard to say if these products will help at all without exercise and changing the way we eat. Certainly, if we exercise and decide to make some positive dietary changes, thermogenic nutrients and herbs can speed up the process.

 

And though dietary change can be a brutally tough process, especially when you’re inactive and used to eating whatever you want, whenever you want, the long-term rewards are more than worth any short-term struggle.

 

What’s the Difference Between Oxyshred and Oxyshred Hardcore?

Apart from the previously discussed higher caffeine content in Oxyshred Hardcore (255mg/serve) versus the original formula (150mg/serve), there are some other differences worth noting.

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The original formulation contains Guggul Extract Powder, Mangifera Seed Extract, Garcinia Cambogia Fruit Extract (60% HCA) and Olive Leaf Extract (10% Oleuropein), while Oxyshred Hardcore does not.

 

However, all is not lost. EHP Labs Oxyshred Hardcore contains Guarana Seed Extract, Evodiamine Fruit Powder and Glycine Propionyl L-Carnitine, which the original formula does not contain.

 

So how does all of this stack up?

 

I’m glad you asked.

 

Evodiamine Fruit Powder, or Evodia rutaecarpa, is believed to assist with the clearance of caffeine from body by enhancing caffeine detoxification enzymes. This means taking Oxyshred Hardcore in the afternoon, evening or night is less likely to interfere with a sound night’s sleep 9.

 

If that’s not interesting enough, Rutaecarpine, an alkaloid found in Evodia rutaecarpa, delivers a range of biological actions, such as vasodilation, and offering antioxidant and natural anti-inflammatory effects 10.

 

woman-posing.jpgAnd then there’s Guarana Seed Extract, which you might be thinking is just another natural source of caffeine. Apart from containing caffeine, however, this seed has been shown to down-regulate genes that promote fat storage and up-regulate genes that support fat burning 11.

 

That’s pretty nifty …

 

Last but far from least is Glycine Propionyl L-Carnitine. If that’s a mouthful, the acronym is GPLC, which rolls off the tongue quite nicely. GPLC has demonstrated the ability to reduce lactate accumulation and enhance peak power and anaerobic performance 12,13.

 

We don’t see a lot of GPLC in powdered products, likely due to the fact that it absorbs moisture like crazy from the air and is notoriously difficult to keep dry. But fear not, EHP Labs know what they’re doing.

 

As for the ingredients not included in Oxyshred Hardcore that are in the original, there really isn’t too much worry about. The three new additions in Hardcore more than make up for their a few exclusions.

 

How to Use Oxyshred Hardcore?

Mix 1 Scoop (4.8 grams) into 300ml cold water and consume 10 minutes before exercise. On non-training days, take one serve first thing in the morning on an empty stomach.

 

Due to the high caffeine content, there is a one serve per day limit on this product.

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Oxyshred Hardcore may be stacked with any number of other pure powders, such as EHP Labs Acetyl L-Carnitine to enhance thermogenesis.

 

If you want to support strength, power and training volume, you can add pure powders of any combination of Citrulline Malate, Betaine, Creatine, Agmatine Sulfate and more as you see fit.

 

Conclusion

EHP Labs Oxyshred Hardcore is a quality pre-workout and thermogenic that may be taken to support a weight loss program or assist with body-fat maintenance.

 

Containing 255mg of caffeine per serve, this product offers a solid kick-start to training motivation and enthusiasm. And with a flavour like Grape Bubblegum, you can be sure that your palate will be grateful.

  

References

  1. Pooyandjoo M et al. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Obesity Reviews, 2016, Vol 17; 10 p. 970-976
  2. Fielding R et al. L-Carnitine Supplementation in Recovery after Exercise. Nutrients, 2018 Vol 10
  3. Plioplys A.V. and Plioplys S. Amantadine and L-carnitine treatment of chronic fatigue syndrome. Neuropsychobiology, 1997 Vol 35;1 p.16-23
  4. Traina G. The neurobiology of acetyl-L-carnitine. Frontiers in Bioscience, 2016 Vol 1;21 p.1314-1329.
  5. Veronese N et al. Acetyl L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis. Psychosomatic Medicine 2018 Vol 80;2 p.154-159
  6. Koozehchian MS et al. Effects of nine weeks L-Carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress in resistance-trained males. J Exerc Nutrition Biochem. 2018 Vol 22;4 p.7-19
  7. Hassle M.E. The Role of Acetylcholine in Learning and Memory. Current Opinion in Neurobiology 2006 Vol 16;6 p.710-715
  8. Krajcovicova-Kudlackova M et al. Correlation of carnitine levels to methionine and lysine intake. Physiological Research. 2000 Vol 49;3 p.399-402
  9. Tsai TH et al. Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in rats. Planta Medica 2005 Vol 71;7 p.640-645
  10. Tian KM et al. Rutaecarpine: A promising cardiovascular protective alkaloid from Evodia rutaecarpa (Wu Zhu Yu). Pharmacological Research 2019 Vol 141 p.541-550
  11. Lima N.da.S., et al. Modulatory Effects of Guarana (Pauillinia cupana) on Adipogenesis. Nutrients. 2017 Vol 9;6 p.635
  12. Jacobs PL et al. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. Journal of the International Society of Sports Nutrition. 2009 Vol 6;9
  13. Jacobs PL and Goldstein ER. Long-term glycine propionyl-l-carnitine supplementation and paradoxical effects on repeated anaerobic sprint performance. Journal of the International Society of Sports Nutrition 2010 Vol 7;35
 

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