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Nitric Oxide Supplements & Muscle Pumps

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GAT Nitraflex
16 (0 reviews)  
25% OFF
Compound X Pre-Workout
19 (1 reviews)  
13% OFF
Vander Kraats The Nitric Factor
1 (1 reviews)  
4% OFF
Axe and Sledge Hydraulic
0 (0 reviews)  
13% OFF
Gen-Tec Arginine AKG
12 (0 reviews)  
ATP Science L-Citrulline Malate
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20% OFF
BSN NO Xplode
25 (1 reviews)  
32% OFF
Faction Labs Bulge
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Total War Pre-Workout
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22% OFF

About Nitric Oxide Supplements & Muscle Pumps

Nitric oxide supplements promote the production of a gas called nitric oxide. Nitric oxide levels play a critical role in the human body, one of which is signalling the smooth muscles surrounding blood vessels to relax. Smooth muscle is a different type of muscle to skeletal muscle, which we use to move limbs. The smooth muscle in blood vessel controls the rate of dilation and constriction, thus altering blood flow.


When the smooth muscle contracts, it constricts the blood vessel, much like pinching a garden hose. When it relaxes, blood vessel dilation occurs (vasodilation), which leads to increased blood flow to the peripheries, including skeletal muscle. Nitric oxide supplements have become popular, as they can increase blood supply and nutrient delivery to muscle tissue, such as oxygen, glucose and amino acids. This may assist with sports and exercise performance and the sensation of muscle fullness (muscle pumps). 


There are many ingredients used in nitric oxide products to increase the synthesis of this gas. Some of the most common are the amino acids agmatine, arginine and citrulline malate, as well as nitrates. Arginine is a conditionally essential amino acid that is used as a building block to produce nitric oxide. Arginine is only one biochemical step away from the gas itself. This makes arginine a common ingredient in nitric oxide boosting supplements. Taking citrulline is an effective way to elevate blood arginine levels, which can then be used for nitric oxide support.


There is a great deal of fascinating research completed in this area, demonstrating that citrulline can elevate arginine levels better than arginine itself. This was reported in the The Journal of Nutrition in 2017. Agmatine is another amino acid that stimulates the activity of the nitric oxide synthase enzyme. This enzyme, unlike the digestive enzymes that break down food, has the special job of manufacturing nitric oxide from arginine. Therefore, agmatine can have a synergistic effect when taken with nitric oxide precursors or building blocks, like arginine or citrulline malate. 


There are many other ingredients used for nitric oxide support, such as nitrates that serve as a building blocks, and herbal extracts, such as hawthorn berries, which strengthen heart muscle contractility thus improving peripheral blood flow. Nitrates are found in beetroot and a range of other vegetables, and promote the synthesis of nitric oxide via an alternative pathway that requires vitamin C. This means nitrates may be taken in addition to vitamin C, Citrulline Malate and Agmatine for well rounded circulatory support.


Nitric oxide supplements are commonly used to improve muscle pumps, vascularity and to improve strength, power and endurance. There are a wide range of flavoured and plain products available, including caffeine-containing supplements and caffeine-free alternatives.