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Acetyl L-Carnitine Supplement

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About Acetyl L-Carnitine Supplement

Acetyl L-Carnitine is an endogenously synthesized dipeptide—I.e., naturally produced—made from the two amino acids lysine and methionine, plus an acetyl group. This form of the dipeptide has been demonstrated in research to cross the blood brain barrier more effectively than other forms of L-Carnitine, meaning that acetyl L-Carnitine not only supports fat metabolism, but also  has some pretty remarkable effects in the brain, and can be classed as a nootropic.


Once this dipeptide enters the brain it is able to donate an acetyl group for the synthesis of acetylcholine, an important neurotransmitter (brain chemical) that is crucial for memory and learning. This amino acid is often used to improve cognitive function, and to assist in managing the signs and symptoms of alzheimer's disease. 


Research published by Frontiers in Bioscience in 2016 indicated that Acetyl-L-Carnitine has antioxidant and neuroprotective effects. This means that it may assist in protecting neurons from damage. Furthermore, it is also believed to be a natural mood enhancer, having a natural anti-depressant effect. 


Acetyl L-Carnitine is great for delivery of the long-chain fatty acids to the cell for oxidation for energy. Therefore, this product may also assist with general energy levels and help to fight fatigue. In fact, a study published in Neuropsychobiology all the way back in 1997 demonstrated that supplementation improved the clinical status of chronic fatigue sufferers. And for a resistant condition that has no medical treatment, this was a pretty impressive finding. Acetyl L-Carnitine is also great for support during weight loss programs, and may also be taken prior to exercise to enhance energy and the fat-burning effect. A comprehensive meta-analysis of the available research up to 2016 indicated that supplementation with Carnitine during a weight loss program leads to 1.33kg more fat loss than placebo. This was published in Obesity Reviews


By definition, Acetyl L-Carnitine is not a stimulant and is typically fine for use in the evening or even before bed. There are many different forms of carnitine, such as carnitine tartrate, GPLC and pure carnitine. However, acetyl-l-carnitine is the only form of carnitine that passes through the blood brain barrier where it supports brain function and can positively impact mood. However, other forms of carnitine will still assist with general energy levels and mitochondrial health outside of the brain.