SAMe was first brought to attention by an Italian, Cantoni in 1951. It was an unstable molecule and could not be studied in clinical trials until it became commercially available in 1974. An Italian group devised a way of stabilizing S-adenosylmethionine by producing a derivative stabilized with p-toluene sulfate.

Since then numerous studies have been carried out showing that SAMe participates in a variety of biological reactions. SAMe has been used clinically in Europe since the 1970's and is today the most prescribed natural supplement for stress, nervous tension, anxiety and low mood in Europe.

"In the USA SAMe became available in 1999 as a dietary supplement and is now the most purchased over-the-counter supplement in the United States!"

Clinical studies using exogenous (oral or parenteral) SAMe have found beneficial effects for those suffering from stress, nervous tension, anxiety, low mood, osteoarthritis, poor liver function as well as a number of other health conditions.